Bij langdurige behandeling met medicijnen is de balans tussen bijwerkingen en het gewenste effect van groot belang.Mensen reageren heel verschillend op beta-blokkers, en daarmee is er geen "beste". Ook de optimale dosering kan tussen personen erg wisselen.Wel is het over het algemeen zo dat beta-blokkers niet werken bij ritmestoornissen die in rust ontstaan, en beter werken bij ritmestoornissen die bij inspanning ontstaan.
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